General Information

Product

PDE4D4 Antibody

Description

Affinity Purified cAMP-specific phoshodiesterase HPDE4D3 variant Antibody N-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide corresponding to unique amino acid sequence on PDE4D4 variant gene.

Accession #

GenBank: EAW74861.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q08499

Overview

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.

Molecular Function

Hydrolase, 3",5"-cyclic-AMP phosphodiesterase activity, cAMP binding

Subcellular Location

Apical cell membrane, Cytoplasm, Membrane

Expression

Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.

Structure

Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1).

Alternative Nomenclature

cAMP specific 3",5" cyclic phosphodiesterase 4D antibody

DKFZp686M11213 antibody

5""-cyclic phosphodiesterase 4D antibody

cAMP specific 3" 5" cyclic phosphodiesterase 4D antibody

cAMP specific phosphodiesterase PDE4D6 antibody

DPDE3 antibody

Dunce like phosphodiesterase E3 antibody

FLJ97311 antibody

HSPDE4D antibody

PDE 43 antibody

Pde4d antibody

Drosophila antibody

STRK 1 antibody