General Information

Product

Particulate Guanylate Cyclase C Antibody

Description

Affinity Purified Guanlylyl Cyclase C Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic C-terminal peptide corresponding to unique amino acid sequences on Particulate Guanylyl Cyclase C protein.

Accession #

GenBank: AAA41201.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-1.20 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Western Blot

1:500

Protein

Uniprot #

P23897

Overview

Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.

Molecular Function

Lyase, Receptor

Subcellular Location

Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane

Structure

Homotrimer. Interacts via its C-terminal region with PDZK2. Interacts with the lectin chaperone VIP36

Alternative Nomenclature

ANP C antibody

ANPRC antibody

Atrial natriuretic peptide C type receptor antibody

Atrionatriuretic peptide receptor C antibody

C5orf23 antibody

FLJ14054 antibody

GUCY2B antibody

MGC22189 antibody

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C) antibody

NPR 3 antibody

NPR C antibody

Guanylyl Cyclase C antibody NPR-C antibody