General Information

Product

ASIC2 Antibody

Description

Affinity Purified Acid-sensing ion channel 2 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-512 on human Acid-sensing ion channel 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q16515

Overview

Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li+ and K+. Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.

Molecular Function

acid-sensing ion channel activity; ion gated channel activity; ligand-gated sodium channel activity

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary.

Structure

Homotrimer or heterotrimer with other ASIC proteins.

Alternative Nomenclature

ACCN1 antibody

Acid sensing ion channel 2 antibody

Amiloride sensitive brain sodium channel antibody

Amiloride sensitive cation channel 1 neuronal antibody

ASIC2 antibody

BNaC1 antibody

Brain sodium channel 1 antibody

Degenerin antibody

Mammalian degenerin homolog antibody

MDEG antibody

Neuronal amiloride sensitive cation channel 1 antibody