General Information

Product

Inhibin alpha Antibody

Description

Affinity Purified Inhibin alpha chain Antibody Mixed Epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptides corresponding to amino acid region taken within 1-50 and 220-270 on Inhibin alpha gene.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

Mixed Epitope

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:20,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P05111

Overview

Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.

Molecular Function

Cytokine activity, hormone activity, growth factor activity, receptor binding

Subcellular Location

Secreted

Expression

Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female.

Alternative Nomenclature

A inhibin subunit antibody

IHA antibody

inhA antibody

INHA_HUMAN antibody

Inhibin alpha chain antibody

Inhibin alpha subunit antibody