General Information

Product

AIM2 Antibody

Description

Affinity Purified Interferon-inducible protein AIM2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Immunogen

Synthetic peptide taken within amino acid region 240-340 on human AIM2 protein.

Accession #

NCBI: NP_004824

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.58 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

O14862

Overview

Innate immune response recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.

Molecular Function

Apoptosis, Immunity, Inflammatory response, Innate Immunity

Expression

Expressed in spleen, small intestine, peripheral blood leukocytes and testis.

Structure

Self-associates; forms homodimers in response to cytosolic dsDNA and the dsDNA serves as oligomerization platform.

Alternative Nomenclature

Absent in melanoma 2 antibody

PYHIN4 antibody